Efficacy of systemic therapy in metastatic adrenocortical carcinoma: a meta-analysis of prospective clinical trials.

ABSTRACT:

Objective

To evaluate pooled prospective trial data investigating efficacy of systemic therapies in metastatic adrenocortical carcinoma (mACC), incorporating subgroup analyses by treatment modality and line, establishing survival and response benchmarks.

Methods

Prospective trials of systemic therapy regimens in mACC published from 2010 to July 2023 were included. Primary endpoints were overall survival (OS), progression-free survival (PFS), and objective response rates (ORRs). ORR was logit-transformed and pooled using a random effects model and inverse variance method. Kaplan-Meier curves for PFS and OS were digitised, and summary curves were constructed using a multivariate extension of the DerSimonian-Laird method.

Results

Across twenty-four studies, 880 patients

SUBMITTER: Shekar S 

PROVIDER: S-EPMC12421987 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature