Transcription factor Hap2p regulates antioxidant stress responses to maintain miconazole resistance in <i>Candida albicans</i>.

ABSTRACT: Acquired resistance in Candida albicans brings about a serious challenge to the clinical application of azoles, so it is urgent to elucidate the mechanisms of azole resistance to improve the therapeutic efficiency. In the aim of searching for the potential targets mediating fluconazole resistance, we screened a mutant library of 48 transcription factor deletion Candida albicans strains. The screening results showed that hap2Δ/Δ mutants were significantly more susceptible to azoles, especially to miconazole (MCZ). Under MCZ treatment, the intracellular reactive oxygen species (ROS) were significantly higher in hap2Δ/Δ mutants compared to the control strain SN250. The addition of antioxidants reversed the MCZ-sensitive phenotype caused by the deletion of HAP2</

SUBMITTER: Qin Y 

PROVIDER: S-EPMC12422037 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature