U-shaped association of body roundness index with all-cause and cardiovascular mortality in individuals with chronic kidney disease.

ABSTRACT:

Purpose

This study aimed to investigate the association between body roundness index (BRI) and deaths from all causes and cardiovascular disease (CVD) in participants with chronic kidney disease (CKD).

Materials and methods

The data was sourced from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Cox proportional hazards regression along with restricted cubic splines were applied to assess the associations of BRI with deaths from all causes and CVD in individuals with CKD.

Results

In total, 8,000 individuals were included in the final analysis. In participants with CKD, there was a nonlinear U-shaped association between BRI and deaths from all causes and CVD, with inflection points at 6.29 and 6.04. When BRI was below the inflection points, ea

SUBMITTER: Huang B 

PROVIDER: S-EPMC12422039 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature