Dermatophytes adaptation to the human host exemplified by <i>Microsporum canis</i>.

ABSTRACT: Dermatophytes are a taxonomic group of keratinophilic fungi that engender cutaneous infections across human and animal populations. The zoophilic species Microsporum canis, which exhibits a widespread distribution, predominantly affects domesticated felines and canines and has recently been associated with an increased risk of human adaptation. This study conducted a comparative genome analysis, validating the adaptive expression of 12 relevant genes through neutrality tests and selection pressure analyses, with a particular focus on the evolutionary mechanisms underlying the transition from zoophilic to anthropophilic Microsporum. The results demonstrated a high degree of consistency in the nuclear and mitochondrial genomes among the three Microsporum species, while s

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12422044 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature