New Experimental Mouse Models to Evaluate the Role of Transforming Growth Factor-Beta in Liver Tumorigenesis.

ABSTRACT:

Background and aims

Hepatocellular carcinoma (HCC) has a poor prognosis and limited treatment options. TGF-β is a promising therapeutic target, but its dual role, as both a tumour suppressor and promoter, complicates its clinical application. While its effects on tumour cells are increasingly understood, its impact on the tumour stroma remains unclear. This study developed novel in vitro and in vivo mouse models to investigate the role of TGF-β in tumour-stroma interactions under immunocompetent conditions, aiming to evaluate its therapeutic potential in liver cancer.

Methods

Mouse liver tumour cell lines were established by hydrodynamic tail vein injection of two different combinations of transposon vector constructions: MYC-LucOS;CTNNB1;SB13 (AL1099 cells) and MYC-Luc;CTNN

SUBMITTER: Cantos-Cortes A 

PROVIDER: S-EPMC12422075 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature