3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine.

ABSTRACT: Neurological disorders impose a substantial global health burden, compounded by the limited regenerative capacity of neural tissues and the absence of curative therapies. 3D bioprinting offers a transformative tool to model, replace, and regenerate neural tissues through the precise spatial organization of cells and biomaterials. In this perspective article, recent advances are examined in: i) the development of in vitro neural platforms for disease modeling and drug screening; ii) bioprinted acellular scaffolds designed to guide endogenous neural repair; and iii) cell-laden constructs that aim to replace or reconstruct damaged neural circuits. Key translational challenges are critically evaluated, including vascularization, immune integration, functional maturation, and replicating the co

SUBMITTER: St Clair-Glover M 

PROVIDER: S-EPMC12422090 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature