A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice.

ABSTRACT: Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow-up visits. The cellular changes in the chondrocytes in injured growth plate have not been fully elucidated, and understanding these factors will provide important insights for the development of therapies that promote growth plate repair and prevent growth arrest. In this study, we refined a mouse growth plate injury model and demonstrated that needle-induced growth plate injury resulted in different healing outcomes depending on the size of the need

SUBMITTER: Matsuoka M 

PROVIDER: S-EPMC12422176 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature