BMP2 alterations in mucinous cystadenocarcinoma of the breast: insights from whole-exome sequencing.

ABSTRACT:

Background

Mucinous cystadenocarcinoma (MCA) of the breast is a rare and distinct type of mammary tract adenocarcinoma. Molecular alterations in breast MCA remain poorly characterized in current epidemiological data.

Methods

We summarized the clinicopathological characteristics and performed exome sequencing on formalin-fixed, paraffin-embedded blocks from three patients with mammary MCA culled from the surgical pathology archives of Chongqing University Cancer Hospital. The tumor mutation landscape of these patients was determined using whole-exome sequencing. We assessed cancer effect sizes and analyzed the contribution of mutational processes to each oncogenic variant, quantifying the extent to which each process contributed to tumorigenesis/cancer effects.

Results

SUBMITTER: Li Z 

PROVIDER: S-EPMC12422278 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature