Preliminary study on metabolite differences between two obesity syndromes based on Q Exactive liquid chromatography-tandem mass spectrometry metabolomics.

ABSTRACT:

Background

According to traditional Chinese medicine, based on the pathogenesis, clinical manifestation, and treatment, obesity can be classified into two broad types, namely, "shi obesity" and "xu obesity." The aim of this study was to explore the differences in metabolite levels between these two types of obesity.

Methods

Q Exactive liquid chromatography-tandem mass spectrometry was used to analyze the metabolites in the sera of 30 healthy adults, 30 adults with shi obesity, and 30 adults with xu obesity. Possible metabolic pathways associated with biological alterations were identified using the Human Metabolome Database and Kyoto Encyclopedia of Genes and Genomes analyses.

Results

Fifteen important potential biomarkers were identified, 14 of which were upregulated

SUBMITTER: Jing Y 

PROVIDER: S-EPMC12422424 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature