Time-restricted feeding leads to sex- and organ-specific responses in the murine digestive system.

ABSTRACT: Food intake is a key regulator of the digestive system function; however, little is known about organ- and sex-specific differences in food-driven regulation. We placed male and female C57Bl/6 mice on time-restricted feeding (TRF), limiting access to food to an 8-hour window. Food was added either at dark (ZT12) or light (ZT0) onset for 14 days. Afterwards, the feeding period was delayed by 4 hours for half the mice, and the respective TRF regime continued for another 14 days. TRF from ZT12 to ZT20 led to the highest weight gain in females and the lowest in males, while improving intestinal transepithelial resistance (TEER) in both sexes. However, it also diminished food-anticipatory gene expression of several hepatic genes, particularly in female mice. Shifting food access to ZT16 increas

SUBMITTER: Oparija-Rogenmozere L 

PROVIDER: S-EPMC12422475 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature