CK2 derived from brain microvascular endothelial cells induces astrocyte inflammatory response in Escherichia coli-induced meningitis.

ABSTRACT: Neuroinflammation within the central nervous system (CNS) is recognized as a critical pathological process in meningitic Escherichia coli (E. coli) infection, leading to severe neurodegenerative disorders and long-term sequelae. Astrocyte reactivity plays a pivotal role in driving the neuroinflammatory cascade in response to pathological stimuli from peripheral sources or other cellular components of the CNS. The involvement of astrocyte reactivity in the inflammatory process induced by bacterial infection within the CNS warrants further investigation. In this study, we observed an astrocyte reaction likely mediated by brain microvascular endothelial cells (BMEC) during meningitic E. coli infection in both a mouse model and a BMEC-astrocyte coculture system. Through label-free quantitative

SUBMITTER: Huo D 

PROVIDER: S-EPMC12422478 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature