Twenty-Year Trends in Colectomy Rates and Advanced Therapy Prescribing in Lothian, Scotland.

ABSTRACT:

Background

The impact of advanced therapy prescribing on colectomy rates in ulcerative colitis (UC) is unknown with conflicting published evidence.

Aim

To describe advanced therapy prescribing trends and colectomy rates for patients with UC in Lothian, UK between January 1st, 2004 and December 31st, 2023.

Methods

We obtained incidence and prevalence data from the Lothian IBD Registry, a rigorously validated population cohort. We report advanced therapy prescribing and colectomy data as raw numbers and annual incidence rates. We used piecewise linear regression analyses to identify temporal trends in prescription and colectomy rates.

Results

The prevalence of UC increased from 216 to 441 per 100,000 population in the 20 years from 2004, culminating in a total of

SUBMITTER: Elford AT 

PROVIDER: S-EPMC12422722 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature