Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome.

ABSTRACT: Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluated the therapeutic potential of a circadian-based intervention in the fragile X mental retardation 1 (Fmr1) knockout (KO) mouse. The Fmr1 KO mice exhibited fragmented sleep, impaired locomotor rhythmicity, and attenuated behavioral responses to light, linked to an abnormal retinal innervation and reduction of light-evoked neuronal activation in the suprachiasmatic nucleus. Behavioral testing revealed significant deficits in social memory and increased repetitive behaviors in the mutants, which correlated with sleep fragmentation. Remarkably,

SUBMITTER: Wang HB 

PROVIDER: S-EPMC12422731 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature