Monocyte Anisocytosis Can Discriminate Between Sepsis and Sterile Inflammation, but not Mortality, in Critically Ill Surgical/Trauma Patients: A Secondary Prospective Analysis.

ABSTRACT:

Objectives background

Monocyte anisocytosis (monocyte distribution width [MDW]) has been previously validated to predict sepsis and outcome in patients presenting in the emergency department and mixed-population ICUs. Determining sepsis in a critically ill surgical/trauma population is often difficult due to concomitant inflammation and stress. We examined whether MDW could identify sepsis among patients admitted to a surgical/trauma ICU and predict clinical outcome.

Design

Secondary analysis of three prospective observational clinical studies.

Setting

Single institution ICU.

Patients/subjects

Two hundred thirty-eight participants were included in this study: 107 patients who were admitted to the ICU and adjudicated to have sepsis, 80 patients who were consider

SUBMITTER: Hernandez-Rios M 

PROVIDER: S-EPMC12422779 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature