Role of R5 pyocin in the predominance of high-risk Pseudomonas aeruginosa isolates.

ABSTRACT: Infections with antimicrobial-resistant pathogens, such as Pseudomonas aeruginosa, are a frequent occurrence in healthcare settings. Although human P. aeruginosa infections are predominantly caused by a small number of sequence types (ST), such as ST235 and ST111, that are frequently multidrug-resistant, the basis for this dominance remains unclear. Using a genome-wide, transposon-insertion library screen, we discovered that the production of R5 pyocins (one of 5 subtypes of R pyocins) confers a competitive advantage to ST111 strains. Competitive dominance was lost by mutants lacking R pyocin production. Analysis of 5135 P. aeruginosa strains revealed that several international, high-risk sequence types (including ST235 and ST111) are enriched for R5 pyocin production, indicating a correla

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12422788 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature