A protective role of SRC-1 against aging associated cognitive decline.

ABSTRACT:

Introduction

Research indicates a strong correlation between obesity and the risk of dementia, both are linked to steroid receptor coactivator-1 (SRC-1), a transcriptional coactivator.

Methods

We used RNA sequencing analysis (RNA-Seq) to investigate the transcriptome of SRC-1-KO mice, and identified S100 calcium-binding protein A6 (S100A6), an AD associated gene, as one target of SRC-1. We tested cognitive behaviors in SRC-1-KO mice and mice with a humanized SRC-1 mutation (SRC-1^L1376P), and performed promoter luciferase assays on S100A6.

Results

Loss of SRC-1 caused alterations in gene signatures that are commonly associated with neurodegenerative diseases, including AD, and diminished the neural plasticity of the hippocampal CA1 neurons. Both SRC-1-KO and

SUBMITTER: Liu H 

PROVIDER: S-EPMC12422791 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature