Age-related trends in amyloid positivity in Parkinson's disease without dementia.

ABSTRACT: Amyloid-beta (Aβ) plays a pivotal role in cognitive decline in Parkinson's disease (PD). The prevalence of amyloid positivity, evaluated using the cerebrospinal fluid (CSF) of patients with PD without dementia in their sixties, is lower than that in individuals with normal cognition without PD diagnosis in the same age range. However, it is unclear whether this is also the case in patients with PD without dementia in their eighties. Eighty-nine patients with PD without dementia were retrospectively classified into two groups with a cut-off age of 73 years at diagnosis: a HIGH group and a LOW group, with mean age at diagnosis of 80.2 and 64.9 years, respectively. The prevalence of amyloid positivity was significantly higher in the HIGH (30.6%) than in the LOW group (10.0%) (p = 0.02)

SUBMITTER: Hatano K 

PROVIDER: S-EPMC12422822 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature