The effect of leukoreduction and prolonged storage on coagulation in cold-stored whole blood: An in vitro study.

ABSTRACT:

Background and objectives

Cold-stored whole blood (CSWB) for haemodynamically unstable bleeding patients is especially convenient when platelets are otherwise unavailable and simple logistics are favoured, as in prehospital situations. Storage times exceeding the currently common 21 days would be beneficial in situations where normal blood processing and distribution is disturbed. To better understand extended-storage CSWB haemostatic properties, we studied leukoreduced CSWB (LR-CSWB) and non-leukoreduced CSWB (non-LR-CSWB) for 5 weeks of cold storage.

Materials and methods

Non-LR-CSWB was donated by seven donors and refrigerated for 5 weeks. Eight units of 20-day-old LR-CSWB returned from clinical rotation unused were stored for an additional 2 weeks. Previously published r

SUBMITTER: Susila S 

PROVIDER: S-EPMC12422834 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature