Sialic Acid-Binding Protein-1 (SABP1) of <i>Toxoplasma gondii</i>: Preliminary Computer-Based Epitope Mapping for Enhanced Vaccine Design.

ABSTRACT: Toxoplasma gondii (T. gondii) infects one third of the human population globally, presenting serious consequences especially in pregnant women or immunosuppressed patients. This study characterized T. gondii sialic acid-binding protein-1 (SABP1) to determine its physicochemical, antigenic, and structural properties as well as immunogenic epitopes using bioinformatics predictions. The amino acid sequence for T. gondii SABP1 was analyzed using ProtParam (physicochemical properties), VaxiJen v2.0 (antigenicity prediction), AllergenFP v1.0 and AllerTOP v2.0 (allergenicity prediction), NetSurfP-6.0 (secondary structure), Robetta (tertiary structure), IEDB, IFNepitope, and IL4pred (immunogenic epitopes). The subcellular prediction was made using signal peptide, transm

SUBMITTER: Gholami S 

PROVIDER: S-EPMC12422853 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature