Case Report: Tislelizumab-induced delayed-onset diabetic ketoacidosis and hypothyroidism in esophageal adenocarcinoma.

ABSTRACT: Immune checkpoint inhibitor-related diabetes ketoacidosis (ICI-DKA) and hypothyroidism are rare but serious adverse events of Anti-programmed cell death-1 (anti-PD-1) therapy, previously unreported in patients with EAC receiving tislelizumab. A 53-year-old man with well-controlled type 2 diabetes and human epidermal growth factor receptor 2 (HER2)-positive metastatic EAC completed 8 cycles of tislelizumab combined with trastuzumab and capecitabine-oxaliplatin (XELOX) chemotherapy, achieving a partial response. Eleven months after the last tislelizumab dose, he presented with fatigue and was diagnosed with DKA and hypothyroidism. Laboratory testing revealed severe insulin deficiency and negative diabetes-related autoantibodies. This was the first reported case of tislelizumab-induced concur

SUBMITTER: Li Z 

PROVIDER: S-EPMC12422895 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature