The influence of gender on CD4⁺ Treg cell function in acute ischemic stroke prognosis.

ABSTRACT:

Objective

This study aimed to evaluate the influence of gender on the prognostic value of CD4⁺ Treg cells in patients with acute ischemic stroke.

Methods

A prospective cohort study was conducted at Minhang Hospital, enrolling 225 patients with acute ischemic stroke. CD4⁺ Treg cell counts were measured by flow cytometry within 24 h of admission, and stroke prognosis was assessed at 3 months using the mRS. Univariate and multivariable logistic regression models were used to identify prognostic factors, and an interaction analysis was conducted to examine whether gender moderated the effect of Treg cell levels on outcomes.

Results

Multivariable analysis revealed that infarct volume (OR = 1.08, 95% CI: 1.03-1.13, p = 0.0028), NIHSS score (OR =

SUBMITTER: Na H 

PROVIDER: S-EPMC12422904 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature