Proteomics reveals periodontitis-driven oxidative stress and lipid metabolism disruption in NAFLD.

ABSTRACT:

Background

Periodontitis is increasingly recognized as a risk factor for non-alcoholic fatty liver disease (NAFLD), yet the underlying mechanisms remain unclear. Oxidative stress and lipid metabolism dysregulation may serve as key pathological links. This study investigates the impact of periodontitis on NAFLD progression and identifies molecular targets involved in hepatic oxidative stress and lipid alterations.

Materials and methods

A rat model of periodontitis was established via molar ligation. Hepatic pathology was assessed using histological staining, biochemical assays, and oxidative stress markers. Proteomic analysis identified differentially expressed proteins (DEPs) associated with lipid metabolism and inflammation. Functional enrichment analysis, protein-protein i

SUBMITTER: Sun B 

PROVIDER: S-EPMC12422905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature