Electrochemical simulation of psychotropic drug metabolism compared to <i>in vivo</i> processes using liquid chromatography and mass spectrometry.

ABSTRACT:

Introduction

Psychotropic drugs strongly affect the human psyche through their ability to modulate the neurotransmitter activity and to treat mental disorders and diseases. Monitoring of psychotropic drugs in clinical studies is significant. Thus. establishing methodologies for analyzing these drugs and their pharmacologically active metabolites in biological matrices is essential for patients' safety. Therefore, therapeutic drug monitoring (TDM) of these drugs in patients receiving pharmacotherapy in psychiatric hospitals is necessary to avoid medical complications, psychiatric adverse effects, or poisoning. In addition to TDM, the main factor in pharmacokinetics that should be monitored along with the drug is its metabolic pathway. The literature on transformation products (TPs)

SUBMITTER: Jerszynska P 

PROVIDER: S-EPMC12422924 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature