Sex Differences in Electrolyte Disturbances Among Diuretic Users According to Renal Function and Age.

ABSTRACT:

Introduction

Diuretics are widely used in Japan for the treatment of hypertension and heart failure. Electrolyte disturbance is a common adverse reaction to diuretics and may be life-threatening. Previous studies have shown that diuretic-induced electrolyte disturbance is more common in women. Electrolyte balance is regulated by the kidneys, and renal function tends to decline with advancing age.

Objective

The aim of this study was to identify patients at high risk of adverse reactions to diuretics, considering the effects of sex, renal function, and age on susceptibility to diuretic-induced electrolyte disturbance.

Methods

Claims data for 67,135 patients on diuretics in Japan were sourced from DeSC Healthcare, Inc. The data covered the period from April 2020 to March

SUBMITTER: Maida N 

PROVIDER: S-EPMC12422990 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature