Clinical utility of comprehensive genomic profiling test for colorectal cancer: a single institution prospective observational study.

ABSTRACT:

Purpose

Next-generation sequencing (NGS) has revolutionized cancer treatment by enabling comprehensive cancer genomic profiling (CGP) to guide genotype-directed therapies. While several prospective trials have demonstrated varying outcomes with CGP in patients with advanced solid tumors, its clinical utility in colorectal cancer (CRC) remains to be evaluated.

Methods

We conducted a prospective observational study of CGP in our hospital between September 2019 and March 2024. Overall survival (OS) of the patients who received CGP-based therapy and those did not was compared, and genomic variables associated with OS were evaluated.

Results

A total of 100 patients with CRC underwent CGP using four platforms. The median patient age was 67 years, and most had a good perform

SUBMITTER: Tanabe H 

PROVIDER: S-EPMC12423004 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature