Clinicopathological evaluation of triple-negative breast cancer treated with keynote-522 regimen.

ABSTRACT:

Background

Our objective is to compare the response rate between two matched cohorts of early-stage TNBC (chemotherapy: CT + immune checkpoint inhibitor: ICI vs CT alone) and to define clinicopathological variables to identify a subgroup of patients who could be spared or benefit from ICI.

Methods

Patients treated with CT + ICI according to KEYNOTE-522 (KN-522) (n = 128) were included in the study and matched 1:1 with patients treated with CT alone. Matching criteria included age range (10 years), race, clinical stage (c)-AJCC, and histological type (metaplastic [MpBC] vs no special type [IC-NST]). The following histological characteristics in the core needle biopsy (CNB) were included: histological type, Nottingham grade, degree of necrosis, and percentage of tumor-infiltra

SUBMITTER: Khoury T 

PROVIDER: S-EPMC12423027 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature