N-acetyl cysteine as an additive to bone cement against pathogens involved in periprosthetic joint infections.

ABSTRACT: Periprosthetic joint infections (PJIs) and septic loosening of implants are common complications following surgical replacement of destructive joints in both human and veterinary medicine. Increasing occurrence of multi-resistant bacteria and failure to manage periprosthetic joint infections make it necessary to identify new antibacterial substances for the treatment and prevention of these infections. N-acetyl cysteine (NAC), a derivative of the amino acid cysteine, has been chosen as a candidate substance due to its shown antibacterial activity. The aim of the study was to evaluate the suitability of NAC for the use together with polymethylmethacrylate bone cement in the context of PJIs. Antibacterial activity of pure NAC and NAC-containing bone cement against clinical isolates of Sta

SUBMITTER: Bohn MC 

PROVIDER: S-EPMC12423035 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature