<i>Lactobacillus salivarius</i> extracellular vesicles enhance gut and liver function in MAFLD.

ABSTRACT:

Background

Metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with an accumulation of fat in the liver, disruptions in lipid metabolism, and imbalances in the gut microbiome. Extracellular vesicles (EVs) derived from probiotics have emerged as potential mediators of host lipid metabolism effect. The precise mechanisms by which EVs derived from probiotics influence MAFLD are still not fully understood.

Methods

We examined the therapeutic potential of EVs sourced from Lactobacillus salivarius SNK-6 (LsEVs) using a mouse model of MAFLD and fatty acids induced cells.

Results

Oral LsEVs administration reduced weight gain, lower liver enzyme levels, and less liver fat in mice. Meanwhile, LsEVs increases the secretion of anti-inflammatory facto

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12423052 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature