Panoramic view of MDH1: driving cancer progression and shaping the tumor immune microenvironment.

ABSTRACT:

Background

Malate dehydrogenase 1 (MDH1), an NAD(H)-dependent isoenzyme, is a key component of the malate-aspartate shuttle (MAS). A significant association has been observed between MDH1 expression and various characteristics of the tumor microenvironment across different cancer types.

Methods

This study provides comprehensive pan-cancer analyses exploring the expression patterns, clinical and pathological correlations, genetic alterations, immunogenomic profiles, single-cell dynamics, alternative splicing signatures, and pharmacological sensitivities related to MDH1. Drug sensitivity profiling and molecular docking techniques have been employed to identify potential anti-cancer compounds targeting MDH1. Experiments have also been conducted to investigate the biological fun

SUBMITTER: Lou Y 

PROVIDER: S-EPMC12423056 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature