CRISPR typing and phage content of colonizing Group B <i>Streptococci</i> from healthy Egyptian women.

ABSTRACT:

Background

Streptococcus agalactiae or Group B Streptococcus (GBS) causes serious infections in neonates with a particularly high burden of disease in Africa. Maternal vaginal colonization is the primary source of neonatal transmission. Molecular surveillance of the maternal GBS population is crucial for informing maternal vaccine development and monitoring of the global circulation of GBS clones.

Methods

The current study analyzes the structure and diversity of the clustered regularly interspaced palindromic repeat (CRISPR)-associated (Cas) system and phage content in colonizing GBS isolates collected from healthy pregnant women from Ismailia, Egypt. The isolates were characterized by whole-genome sequencing within the global JUNO project.

Results

CRISP

SUBMITTER: Shabayek S 

PROVIDER: S-EPMC12423071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature