Analysis of serum amino acids and tryptophan metabolites to predict hepatic encephalopathy in portal hypertension patients receiving a transjugular intrahepatic portal shunt (TIPS).

ABSTRACT:

Introduction

The incidence of hepatic encephalopathy (HE) after transjugular intrahepatic portal shunt (TIPS) is over 30%, how to decrease the occurrence rate of HE is one of the most challenging issues after TIPS surgery. The aim of this study is to identify the potential biomarker that can predict the occurence of HE after TIPS in patients with portal hypertension (PH), and provide the theoretical support for early clinical diagnosis and prevention.

Methods

A total of 50 patients with PH underwent TIPS were enrolled with completed clinical information in this study, and they were divided into two groups with or without the complications of HE.

Results

We quantitatively determined 20 serum amino acids, and found that 4 amino acid levels were increased significantly i

SUBMITTER: Bao L 

PROVIDER: S-EPMC12423102 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature