Association between maternal glucose levels in pregnancy and offspring's metabolism and adiposity: an 18-year birth cohort study.

ABSTRACT:

Aims/hypothesis

The study aimed to explore the association between maternal glucose levels in pregnancy and offspring's metabolism and adiposity at approximately 18 years of age.

Methods

Pregnant women from the Hong Kong Field Centre enrolled in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study underwent a 75 g OGTT at 24-32 gestational weeks. Offspring's metabolic and adiposity traits were assessed at 18 years postpartum. Associations were evaluated using multiple linear regression and logistic regression.

Results

Among the 506 mother-child pairs followed up to 18 years, maternal fasting plasma glucose (FPG) in pregnancy was positively associated with offspring's FPG (β = 0.06 [95% CI 0.02, 0.09]), while maternal 1 h plasma glucose (PG) showed a positive a

SUBMITTER: Deng Y 

PROVIDER: S-EPMC12423139 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature