Navigating disclosure in new romantic partnerships as an adolescent or young adult with Li-Fraumeni syndrome.

ABSTRACT: Li-Fraumeni syndrome (LFS) is an early-onset cancer syndrome caused by pathogenic germline TP53 variants. Adolescents and young adults (AYAs) with LFS may have challenges navigating new romantic partnerships given the significant effects of LFS on multiple life domains that also affect partners (e.g., reproductive decision-making). Disclosing LFS-related information to new partners may be especially difficult given the uncertainty, complexity, and chronicity of LFS. This qualitative-descriptive study aimed to explore AYAs' LFS disclosure decisions and experiences in new romantic partnerships. Participants were individuals with LFS aged 15-39 years at enrollment in a National Cancer Institute study. The analytic sample included 33 AYAs who completed at least one telephone interview. Greene'

SUBMITTER: Rising CJ 

PROVIDER: S-EPMC12423177 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature