Risk of New-Onset Atrial Fibrillation in Opioid Users: A Systematic Review and Meta-Analysis on 24,006,367 Participants.

ABSTRACT:

Background

Despite ongoing efforts, the prescription of opioids is still common. Long-term opioid use has been associated with an increased risk of adverse cardiovascular outcomes.

Objective

We aimed to evaluate the association between opioid use and the risk of new-onset atrial fibrillation.

Methods

We performed a systematic review and meta-analysis of studies retrieved from MEDLINE and EMBASE databases according to PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines from inception to 29 January, 2024. The protocol was registered at PROSPERO (CRD42024512500). Two authors independently screened and extracted data from included studies. The quantitative analysis included only observational studies and results were synthesised by a poo

SUBMITTER: Menichelli D 

PROVIDER: S-EPMC12423187 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature