ChatGPT versus DeepSeek in head and neck cancer staging and treatment planning: guideline-based study.

ABSTRACT:

Purpose

This prospective simulation study was conducted to evaluate and compare the performance of ChatGPT (o1, 2023) and DeepSeek (V3, 2024) in staging and treatment planning for head and neck cancers.

Methods

This prospective simulation study was conducted in March 2025 to evaluate and compare the performance of two advanced artificial intelligence (AI) models, ChatGPT (o1, 2023) and DeepSeek (V3, 2024), in clinical decision-making for head and neck malignancies. A total of 50 hypothetical, guideline-based clinical scenarios were carefully designed in English by two otorhinolaryngologists in alignment with the National Comprehensive Cancer Network® (NCCN®) Guidelines Version 2.2025.

Results

In the overall analysis of treatment planning performance, DeepSeek (V3, 202

SUBMITTER: Vural Camalan B 

PROVIDER: S-EPMC12423241 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature