Vasculogenic potential of adipose tissue derived stem cells from patients with chronic spinal cord injury and pressure injuries.

ABSTRACT: Limited vascularization and ischemia are major contributors to the chronicity of wounds, such as ulcers and traumatic injuries, which impose significant medical, social, and economic burdens. These challenges are particularly pronounced in patients with spinal cord injury (SCI), a disabling condition associated with vascular dysfunction, infections, and impaired peripheral circulation, complicating the treatment of pressure injuries (PIs) and the success of reconstructive procedures like grafts and flaps. Regenerative medicine aims to address these issues by identifying effective cellular therapies to restore vascular beds. Among these, cells from the stromal vascular fraction (SVF) of adipose tissue (AT) are promising due to their abundance of angiogenic and vasculogenic cells, including

SUBMITTER: Santos-De-La-Mata A 

PROVIDER: S-EPMC12423250 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature