Flexible Parametric Accelerated Failure Time Models With Cure.

ABSTRACT: Accelerated failure time (AFT) models offer an attractive alternative to Cox proportional hazards models. AFT models are collapsible and, unlike hazard ratios in proportional hazards models, the acceleration factor-a key effect measure in AFT models-is collapsible, meaning its value remains unchanged when adjusting for additional covariates. In addition, AFT models provide an intuitive interpretation directly on the survival time scale. From the recent development of smooth parametric AFT models, we identify potential issues with their applications and note several desired extensions that have not yet been implemented. To enrich this tool and its application in clinical research, we improve the AFT models within a flexible parametric framework in several ways: we adopt monotone natural spl

SUBMITTER: Akynkozhayev B 

PROVIDER: S-EPMC12423370 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature