Quantitative MRI Dixon signal drop and fat fraction for differentiating bone marrow lesions: a two-center prospective analysis.

ABSTRACT:

Background

Bone marrow (BM) lesion differentiation remains challenging, and quantitative magnetic resonance imaging (MRI) may enhance accuracy over conventional methods. We evaluated the diagnostic value and inter-reader reliability of Dixon-based signal drop (%drop) and fat fraction percentage (%fat) as adjuncts to existing protocols.

Materials and methods

In this prospective two-center study, 172 patients with BM signal abnormalities underwent standardized 1.5-T MRI protocols, including Dixon sequences. Two musculoskeletal radiologists independently evaluated images and performed quantitative measurements of %drop and %fat. Final diagnoses were established through histopathology (n = 96) or imaging follow-up (n = 76). Diagnostic value was assessed using area under the rece

SUBMITTER: Metwally MI 

PROVIDER: S-EPMC12423374 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature