Gene-Diet Interaction Analysis in UK Biobank Identified Genetic Loci That Modify the Association Between Fish Oil Supplementation and the Incidence of Dementia.

ABSTRACT:

Background

Dementia is a common disease influenced by both genetic and environmental factors. APOE ε4 is well-known to increase risk of dementia, and it has been shown to attenuate the protective association of fish oil supplements (FOS) and the incidence of dementia.

Objectives

To identify additional genetic factors with modifying effects, we performed a genome-wide scan.

Methods

We performed genome-wide association studies (GWAS) of incident all-cause dementia, Alzheimer's disease, and vascular dementia in 357,631 participants from UK Biobank and the FOS subgroups. Single-nucleotide polymorphisms (SNPs) suggestively associated with dementia (P < 1 × 10^-5) were then evaluated for their interactions with fish oil status in Cox regression model

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12423404 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature