Causal Effects of Immune Cell Populations on Cognitive Performance: A Mendelian Randomization Study.

ABSTRACT:

Background

Recent research has started to uncover an important connection between immune system activity and cognitive abilities. Although correlative associations have been documented, the causal mechanisms connecting specific immune cell subpopulations to cognitive capabilities remain insufficiently characterized. Our research aimed to determine directional relationships between distinct immune cell subtypes and cognitive function, potentially identifying targets for immunomodulatory interventions.

Methods

We performed a two-sample Mendelian randomization (MR) analysis using genome-wide association study data from 3757 Sardinian individuals, paired with detailed immunophenotyping. We also incorporated cognitive performance summary statistics from the cohort described by Le

SUBMITTER: Fu J 

PROVIDER: S-EPMC12423432 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature