Microbiome Signatures and Dysbiotic Patterns in Oral Cancer and Precancerous Lesions.

ABSTRACT:

Background

The oral microbiome has been shown to be associated with the development of oral squamous cell carcinoma (OSCC). Research has primarily focused on elucidating the oncogenic mechanisms of specific pathogens by comparing the microbiomes of OSCC and normal tissues. However, the characteristics of the microbiome in the precancerous state remain less understood, as does the influence of metabolic and environmental factors on OSCC-associated microbiomes.

Methods

In this study, we analyzed mucosa-associated microbiomes in normal, precancerous, and OSCC lesions from a cohort of 51 patients using 16S rRNA amplicon sequencing. We investigated compositional changes in the microbiome, including the specific abundances and co-occurrences of OSCC-associated bacteria.

Results

SUBMITTER: Yang CC 

PROVIDER: S-EPMC12423479 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature