Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach.

ABSTRACT:

Background

Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic syndrome. We (a) measured its level in persons with diabetes mellitus, (b) constructed a family tree of the enzyme using nucleotide sequences downloaded from NCBI. Butyrylcholinesterase was estimated colorimetrically using a commercially available kit (Randox Lab, UK). Phylogenetic trees were constructed by distance method (Fitch and Margoliash method) and by maximum parsimony method.

Results

There was a negative correlation between serum total cholesterol and butyrylcholinesterase (-0.407; p < 0.05) and between serum LDL cholesterol and butyrylcholinesterase (-0.435; p < 0.05). There was no statistically significant correlation among the other biochemical parameters. In the evolutionary tr

SUBMITTER: Sridhar GR 

PROVIDER: S-EPMC1242349 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature