The shifting paradigm of chromatin structure: from the 30-nm chromatin fiber to liquid-like organization.

ABSTRACT: The organization and dynamics of chromatin are critical for genome functions such as transcription and DNA replication/repair. Historically, chromatin was assumed to fold into the 30-nm fiber and progressively arrange into larger helical structures, as described in the textbook model. However, over the past 15 years, extensive evidence including our studies has dramatically transformed the view of chromatin from a static, regular structure to one that is more variable and dynamic. In higher eukaryotic cells, chromatin forms condensed yet liquid-like domains, which appear to be the basic unit of chromatin structure, replacing the 30-nm fiber. These domains maintain proper accessibility, ensuring the regulation of DNA reaction processes. During mitosis, these domains assemble to form more ge

SUBMITTER: Maeshima K 

PROVIDER: S-EPMC12423499 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature