Gut Commensal Antibiotic-Resistant <i>Parabacteroides goldsteinii</i> Ameliorates Mouse Colitis through Valine-Isobutyrate Metabolism.

ABSTRACT: Antibiotic cocktails (ABX) serve as potent therapeutic interventions for refractory ulcerative colitis (UC), yet invariably induce gut dysbiosis. This study demonstrates that pectin oligosaccharides synergistically enhance ABX efficacy by restoring gut microbiota balance and selectively enriched antibiotic-resistant Parabacteroides goldsteinii in a colitis mouse model. Our results further indicate that the gavage administration of P. goldsteinii AM58-2XD markedly alleviated colitis via enhancing the branched-chain amino acid metabolic pathway, particularly by facilitating valine metabolism. Notably, these anticolitis effects were partially attenuated in P. goldsteinii ^ΔilvE mutants, which are defective in valine-derived isobutyrate (IBN) biosynthesis. We fur

SUBMITTER: He N 

PROVIDER: S-EPMC12423503 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature