Indoor radon concentration and risk and severity of inflammatory bowel diseases: a case-control study.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) develops from a dysregulated immune response influenced by environmental exposures. Radon, a radioactive gas, has known biological effects, but its role in IBD remains unexplored.

Objectives

To examine the association between residential radon exposure and the risk and clinical course of IBD.

Design

A case-control study with 1-year prospective follow-up of cases.

Methods

We included 178 newly diagnosed IBD patients and 178 age- and sex-matched controls in Santiago de Compostela, Spain, from June 2020 to September 2023. Residential radon levels were measured using passive detectors for 3 months. Outcomes included IBD diagnosis, disease extent, hospitalizations, and flares. Logistic regression was used to estimate odds

SUBMITTER: Mauriz-Barreiro V 

PROVIDER: S-EPMC12423541 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature