Bi-Layered Biphasic Calcium Phosphate Bone Substitute to Improve Bone Formation in Lateral Jaw Defects Applying the Principle of Guided Bone Regeneration (GBR)-A Pre-Clinical Randomized Controlled Study.

ABSTRACT:

Aim

To evaluate the application of a synthetic bi-layered biphasic calcium-phosphate (BBCP) bone substitute for its capacity for new bone formation in Guided Bone Regeneration (GBR) in an acute-defect model in Beagle dogs.

Material and methods

Standardized bone defects were created following the extraction of the maxillary ¹P¹, ²P², ⁴P⁴ and the mesial root of ³P³ in six Beagle dogs. The defects were treated according to the GBR principle using the tested material, synthetic bi-layered biphasic calcium-phosphate bone substitute (Group T), deproteinized bovine bone mineral (DBBM, positive control = PC), a mixture of the test substance and DBBM in a ratio of 1:1 (Group M) and a sham-operated

SUBMITTER: Lang KN 

PROVIDER: S-EPMC12423585 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature