Long-term effects of influenza and Bacille Calmette-Guerin vaccination on systemic inflammation.

ABSTRACT:

Objective

Chronic systemic inflammation can lead to metabolic, cardiovascular and neurodegenerative complications, but the factors influencing it are incompletely understood. In this study, we evaluated several factors, including Bacille Calmette-Guérin (BCG) and influenza vaccination, SARS-CoV-2 infection and sex, that may impact systemic inflammation as assessed by targeted inflammatory plasma proteome analysis in healthy individuals.

Methods

Participants were randomised to BCG or placebo vaccination at the start of the Dutch SARS-CoV-2 epidemic in March/April 2020. They reported their influenza vaccination status for the most recent influenza season. Twelve weeks after BCG or placebo vaccination, we assessed relative concentrations of 69 proteins in plasma of 357 individu

SUBMITTER: Debisarun PA 

PROVIDER: S-EPMC12423592 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature