A multifunctional living hydrogel for the synergistic management of infected diabetic wounds.

ABSTRACT: The primary causes of poor healing in diabetic wounds are bacterial infection, immune imbalance, and chronic inflammation. In this study, we employed the "fighting bacteria with bacteria" strategy to develop a dynamic living hydrogel system that comprehensively coordinates antibacterial, antioxidant, and regenerative functions for infectious diabetic wounds. Through engineered integration of functionalized probiotics and adaptive hydrogel networks, Lactobacillus rhamnosus CLK 101 (LRh) was biosynthesized with intracellular nano-selenium (nanoSe) and surface-coated with ceramide (CAD). The probiotics were then encapsulated within a biocompatible phospholipid polymer hydrogel that maintained probiotic viability. This living hydrogel system synergistically accelerated healing th

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12423598 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature