Membrane-Modifying Effects of Perfluoroalkyl Substances in Model Bacterial Membranes.

ABSTRACT: Understanding the interactions of per- and polyfluoroalkyl substances (PFAS) with bacterial membranes is essential for evaluating their ecological and health impacts. To mimic the diverse environments found in bacterial membranes, we constructed model membranes as bilayers, liposomes, and supported bilayers using binary lipid mixtures of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), with 1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) (DOPG)all sharing the same acyl chains but differing in headgroup types and charges. Our findings demonstrate that salts of perfluorooctanoic acid (PFOA) and perfluorobutanesulfonic acid (PFBS) induce concentration- and lipid-dependent disordering effect in memb

SUBMITTER: Panella M 

PROVIDER: S-EPMC12423796 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature