Conformational Variability Prediction of H5N1 Avian Influenza A Virus Hemagglutinins with Amino Acid Mutations Using SSSCPreds.

ABSTRACT: The worldwide outbreak of the highly pathogenic avian influenza (HPAI) H5N1 virus has sent egg prices soaring. Concomitantly, bovine and human infections of H5N1 viruses have also been observed, but there is no known person-to-person spread. The shape of the motifs is important for receptor recognition of viruses and is contradictorily deformed with amino acid mutations to avoid immunity. The deep neural network-based conformational variability prediction system of protein structures (SSSCPreds) suggests that the outbreak of HPAI is occurring in the avian world, just as the outbreak of SARS-CoV-2 was seen in the human world. The predicted flexible motif with the mutations N236K/Q238L of the B3.13 virus rationally explained the difference of specificity switching by the mutations between B3

SUBMITTER: Izumi H 

PROVIDER: S-EPMC12423806 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature